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Report研究成果

2022年

原著論文

Yamamoto-Imoto, H., Minami, S., Shioda, T., Yamashita, Y., Sakai, S., Maeda, S., Yamamoto, T., Oki, S., Takashima, M., Yamamuro, T., Yanagawa, K., Edahiro, R., Iwatani, M., So, M., Tokumura, A., Abe, T., Imamura, R., Nonomura, N., Okada, Y., Ayer, E. D., Ogawa, H., Hara, E., Takabatake, Y., Isaka, Y., *Nakamura S., *Yoshimori T. Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis. Cell Rep, 38, 110444, (2022)


Yamamuro, T., *Nakamura S., Yanagawa, K., Tokumura, A., Kawabata, T., Fukuhara, A., Teranishi, H., Hamasaki, M., Shimomura, I., *Yoshimori, T., Loss of Rubicon in adipocytes mediates the upregulation of autophagy to promote the fasting response. Autophagy, 14, 1-11, (2022).


Murakawa, T., Nakamura, T., Kawaguchi, K., Murayama, F., Zhao, N., Stasevich, T., Kimura, H., Fujita, N.
A Drosophila Toolkit for HA-tagged Proteins Unveiled a Block in Autophagy Flux in the Last Instar Larval Fat Body.
Development (2022) 149 (6): dev200243

https://doi.org/10.1242/dev.200243

蛹期の擬似的な飢餓に備えてショウジョウバエ幼虫脂肪体のリソソーム活性が抑制されることを示す成果がDevelopmentに掲載されました。

プレスリリース
https://www.titech.ac.jp/news/2022/063216


Ogura, M., Shima, T., Yoshimori, T., *Nakamura, S. Protocols to monitor TFEB activation following lysosomal damage in cultured cells using microscopy and immunoblotting, STAR Protoc. 3, 101018, (2022)

https://hivebench-star-protocols.s3.amazonaws.com/protocols/1290.pdf

オートファジー・リソソーム生合成のマスター転写因子TFEBの活性をモニターするプロトコル論文がSTAR Protocolsに掲載されました。


総説

*Nakamura, S., Shioda, T., *Yoshimori, T. Autophagy in aging and longevity (Chapter12), Aging Mechanism II: Longevity, Metabolism and Brain Aging (Springer) (2022)


Cui, M., *Yoshimori, T., *Nakamura, S. Autophagy system as a potential therapeutic target for neurodegenerative diseases. 155, 105308, Neurochem Int, (2022)


*Nakamura, S., Akayama, S., *Yoshimori, T. Non-canonical roles of ATG8 for TFEB activation. Biochem Soc Trans. 50, 47-54, (2022)


Minami, S., *Nakamura, S., *Yoshimori, T. Rubicon in Metabolic Disease and Aging. Front. Cell Dev. Biol., 9, 816829, (2022)


中村修平、吉森保「オートファジーと老化・神経変性疾患」老年精神医学雑誌 33, 79-86, 2022年